Regenerative medicine for animals
ReGenesis is a leading biomed company in regenerative medicine. We provide doctors and veterinarians with high-quality products for the treatment of their patients.
The three fundamentals in regenerative medicine are: scaffolds, cells and growth factors. Based on that premise ReGenesis has been able to develop a fully biocompatible scaffold that induces the naturally occurring regenerative process of animals. Tissue growth starts to take place due to signals and cell migration that create the appropriate environment and allows the healing of the tissue.
With experience in human regenerative medicine, Regenesis brings to the veterinary medicine market the opportunity to provide superior animal care. We have been able to create not only a product, but a protocol that can improve animals’ quality of life.
- ReGenesis ECM stimulates the naturally-occurring healing process without immunological rejection.
- ReGenesis ECM has adjustable mechanical properties and appropriate biocompatibility.
- ReGenesis ECM is an effective alternative option for clinical treatment of tissue damage.
ECM benefits:
Surgical applications
- Soft tissue repair.
- Degloving injuries.
- Dental treatments.
- Alternative to skin grafts.
Wound Managment
Regenesis ECM functions as a barrier, guides cells and growth factors naturally produced by the body to invade the damaged organ, inducing the healing process at the site of injury.
As Regenesis ECM is able to help in animal wound care, in addition to wounds produced by trauma, accidents or by any other means, Regenesis ECM has been proved to be a great choice for burn healing.
Neurology
Regenesis ECM due to its properties is a great choice for veterinary neurology applications. Due to the biocompatibility of the material, it does not induce immunological or inflammatory responses and is nontoxic and it is absorbed without adhesion to the normal surrounding tissue (cerebral cortex or bone).
For neurological applications, Regenesis ECM is a multi-layered product that is able to provide the necessary mechanical properties.
Properties
Biocompatibility
The membrane must provide an acceptable level of biocompatibility. The interaction between the material and tissue should not adversely affect the surrounding tissues, the intended healing outcome, or the overall safety of the patient.
Space for growth
The membrane must have adequate stiffness to create and maintain adequate space for the intended regeneration. The material must also be adequately malleable to provide the specific geometry required for tissue reconstruction and regeneration.
Appropriate environment
It has been established that tissue occlusiveness is an important factor in preventing connective tissue invasion and allowing bone-forming cells to grow freely.
Tissue integration
Tissue integration is the key aspect of all tissue regeneration techniques, as it is essential that the membrane is reabsorbed by the host tissue.
Easy clinical handling
A membrane must be easy to handle during clinical use. A membrane that is difficult to use, such as one that is too malleable, can be troublesome, often lead to complications and cannot be used reproducibly in a clinical setting.
Manufacturing process
The ultimate goal is to remove all cellular components through a non-harmful process that maintains the structure and function of the source tissue. The more biocompatible the final product is to the host, the less likely it is to cause an adverse reaction. However, the products used in the manufacture of the ECM may degrade the source tissue structure or remove growth factors that are bound to the ECM components. This can lead to rapid degradation and resorption of the matrix by the host and result in scar tissue formation. An adverse reaction may be indicated by inflammation with accumulation of cells around the edges of the matrix, preventing cellular or vascular infiltration (encapsulation).
The ideal response is minimal inflammation and gradual degradation of the matrix over time with complete integration within the host tissue. Therefore, how a product is manufactured may be more important to the function of the product than the source, species and location from which the tissue was extracted.
Sterilization
Sterilization is important to reduce the risk of disease transmission and is required for all animal-derived products. However, residual chemicals used during the sterilization process (e.g., ethylene oxide [EtO] or gluteraldehyde) can produce an inflammatory response within the host tissue and radiation can damage the matrix, causing it to break down and be absorbed too quickly.